Mix a small amount with other treatments in the palm of your hand and apply to face in the AM or the PM. Avoid contact with the eyes. A tingling sensation can be expected after application. Do not mix with formulations containing Niacinamide or EUK 134. If irritation occurs, cease use and consult a physician. Use only as directed on unbroken skin. Patch testing prior to use is advised. Keep out of reach of children.